Albumen preparation from albuminoids and salts of guaiacol-sulfonic acids.



ALBERT BUSCH, OF BRUNSWICK, GERMANY, ASSIGNOR 'IO FIRM OF BAUER 8c CIR, OF BERLIN, GERMANY.

ALBUMEN PREPARATION FROM ALBUMINOIDS AND SALTS OF GUAIACOL-SULFONIC ACIDS.

No Drawing.

To all whom it may concern:

Be it known that I, ALBERT Boson, a subject of the Duke of Brunswick, residing in the city of Brunswick, in the Duchy of Brunswick, German Empire, have invented a certain new and useful Manufacture of Albumen Preparations Soluble in WVater from Albuminoids and Salts of the Guaiacol-Sulfonic Acids, of which the following is a specification.

y basic soluble salts of the guaiacol-sulfonicacids directly in a pure concentrated solution with certain albuminoids viz. albuminates, casein of milk or vegetable casein. In this manner the crystallization of the guaiacol sulfonic acid salts is not only avoided, but it is possible to produce an antiphthisic, which contains besides the antiphthisical salts of guaiacol-sulfonicacids at the same time an excellent food of high nutritive value. Moreover, while the salts, especially the isomeric basic sodium salts of the guaiacol-sulfonic-acids OCH (3 H, O.Na.

SO Na have rather a bitter and alkaline taste, the new composition is quite tasteless and therefore particularly suitable for therapeutic use.

The isomeric guaiacol-sulfonic-acids mentioned above are formed simultaneously by treating guaiacol with concentrated sulfuric acid at temperatures below 100 degrees centigrade (compare Paul, Berta/rte (Zcr Deutchcn O/Lcmschcn Gcsellschaft Vol. 39 page 2773). The potassium salts of these acids are the easiest to be obtained, but they are, like all soluble potassium salts, heart poisons. The sodium salts are more suitable, but their crystallization is dillicult. By this invention it is possible'to obtain a product which contains the difficultly crystallizable sodium salts. The crystallization of the sodium salts is in this manner avoided.

The preparation of the basic sodium salts of the guaiacol-sulfonic-acids may be carried out in the following manner: Guaiacol is sulfonated by means of concentrated sulfuric acid, the mixture is then diluted with icewater, the excess of free sulfuric acid is removed by adding the exact quantity of barium hydrate or barium carbonate. Then Specification of Letters Patent.

Application filed December 28, 1909.

invention consists in combining the 'tain limits.

Patented Dec. 2'7, 1910.

Serial No. 535,330. (Specimens) filter and saturate the filtrate with slaked lime, whereby the mixture of basic lime salts is precipitated. This mixture of lime salts is converted into the basic sodium salts of the isomeric guaiacol-sulfonic-acids by boiling them with water and the equivalent quantity of carbonate of soda or sodium hydroXid, filtering oil' the deposit of carbonate or hydrate of lime and concentrating the filtrate.

The process of manufacturing the albuminoid preparations mentioned above, can be effected in several ways. Good practical results will be obtained from the process described hereafter.

Example 1: 100 parts by Weight of albuminous matter, for instance casein of milk are mixed to a paste with a small quantity of cold water. Then 28 parts by weight of a 25% solution of basic sodium salts of guaiacol acids are added and the mixture is warmed to 40 degrees centigrade. On adding some boiling water say 400 parts, a solution will result which is filtered and evaporated at 30%0 degrees centigrade preferably in cacao. The residue is ground and finely sifted; it constitutes a white, well keeping odorless and tasteless water soluble powder with about 6.5 per cent. of guaiacol-sulfonicacid salts, absorbing cold water and swelling and dissolving by heat to a milky white liquor.

Example 2: 100 parts by weight of albuminous matter, for instance casein of milk, free from fat and finely sifted, are made into a paste with a mixture of 100 parts by weight of alcohol (92 to 96%) and 100 parts by weight of ether. Then 28 parts by weight of a 25% solution of basic sodium salts of the guaiacol-sulfonic-acids are caused to flow under constant stirring into this mixture. After some time, say an hour, filter, wash the residue with other and dry it at a low temperature say 300 degrees centigrade. After being ground and sifted, the product forms a white, odorless and tasteless, well keeping powder, containing about 6.5 per cent. of guaiacol-sulfonic-acid salts.

The strength of the 25 per cent. solution of guaiacol-sulfonic-acid-salts used under Examples 1 and 2 may be varied within cer- It is necessary however, that 57 parts by weight of the basic sodium salts of the guaiacol-sulfonic-acids, figured as dry, should be used for one hundred parts by weight of the casein, above mentioned, in order to obtain soluble products.

Instead of the basic sodium salts of the guaiacol-sulfonic-acids any other mixtures of basic soluble salts of the guaiacol-sulfonic acids such as lithium salts or potassium salts may be used. In order to obtain those proclucts it is only necessary to substitute the basic sodium salts of the guaiacol-sulfonicacids of Examples 1 and 2 by the corresponding basic sulfonic-acid-salts.

The suspension of the casein in the liquid under Example 1 may be effected by any other indifierent organic liquid besides ether-alcohol, in which the albuminoids and the guaiacol-sulfonic-acid-salts are insoluble, such as methylic spirit, acetone, etc.

I claim:

1. The process of manufacturing albumen preparations soluble in water from albuminoids such as albuminates, casein of milk or vegetable casein and basic soluble salts of guaiacol-sulfonic-acids consisting in combining said albuminoids with concentrated solutions of the basic sodium salts of the guaiacol-sulfonic-acids, substantially as setforth.

2. The process of manufacturing albumen preparations soluble in water, from albuminoids such as albuminates, casein of milk or vegetable casein and basic soluble salts of guaiacol-sulfonic-acids consisting in suspending the albuminoids in inactive liquids and mixing to them basic soluble salts of guaiacol-sulfonic-acids, then removing the inactive liquid by filtration and drying the product, substantially as set forth.

3. As a new article of manufacture the above described Water soluble product obtained by combining albuminoids such as albuminates, casein of milk or vegetable casein and basic soluble salts of guaiacolsulfonic-acids in form of a powder white in color, odorless and tasteless, absorbing cold water and swelling up and dissolving by heat to a milky white liquor, substantially as described.

Signed by me at Brunswick, Germany, this 13th day of December, 1909.

ALBERT BUSCH. 

